Can Thymic Tissue Induce Tolerance to Kidney Allografts?

• Main Authors: Nader Tanideh, Ahmad Monabbati, Abdolaziz Khezri, Alireza Aminsharifi, Saeed Shakeri
• Format: Article
• Language: English
• Published: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences 2005-04-01
• Series: Urology Journal
• Online Access: http://www.urologyjournal.org/index.php/uj/article/view/238/235
• ISSN: 1735-1308; 1735-546X

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mso-style-locked:yes; mso-style-link:"Body Text"; mso-ansi-font-size:12.0pt; mso-bidi-font-size:12.0pt; font-style:italic;} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt;} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 72.0pt 72.0pt 72.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> <!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--> <p class="MsoNormal" style="text-align: left; direction: ltr; unicode-bidi: embed;"><strong><span>Introduction:</span></strong><span> The aim of this study was to investigate the beneficial effect of donor thymic tissue to induce tolerance in thymokidney allografts, transplanted to thymectomized cross-bred canines.</span></p> <p class="MsoBodyText" style="text-align: left; line-height: normal;" align="left"><strong><span style="font-style: normal;">Materials and Methods<span>: </span></span></strong><span style="font-style: normal;">Seven pairs of transplant donors and recipients were selected from </span><span style="font-style: normal;">3- to 4-month-old cross-bred canines<span> with major histocompatibility complex (MHC) mismatches. Recipients underwent partial thymectomy 4 weeks before transplantation and received an autologous thymic graft under the renal capsule, which had been engrafted in the donors 3 months before transplantation (thymokidney). Successful engraftment with evidence of thymocyte development in the donors was determined by gross and histologic examination at the time of transplantation. Biopsy specimens were obtained at the transplant day and 3 months after transplantation and were studied histologically for evidence of hyperacute or acute rejection.</span></span></p> <p class="MsoBodyText" style="text-align: left; line-height: normal;" align="left"><strong><span style="font-style: normal;">Results: </span></strong><span style="font-style: normal;">At 90 days after the operation, all 7 juvenile thymic grafts had developed with normal thymic structure under the renal capsule. Hyperacute rejection was not observed in allografts, and all of them were functioning until the end of follow-up; however, all of the allografts showed acute cell-mediated rejection 3 months after transplantation.<strong> </strong></span></p> <strong><span style="font-size: 12pt; font-family: ">Conclusion: </span></strong><span style="font-size: 12pt; font-family: ">N<span>o tolerance was induced by vascularized donor thymokidneys in MHC-mismatched canines. The advantages of tolerance over chronic immunosuppression are so great that a potentially tolerogenic approach such as thymic transplantation would seem worthy of further investigations</span> on large animal models. <span>To evaluate the beneficial effects of thymic tissue in tolerance induction, utilizing a short course, low-dose adjuvant immunosuppressant to this regimen and/or application of in-bred MHC-matched canines is suggested.</span></span>