Mouse Lymphoblastic Leukemias Induced by Aberrant Prdm14 Expression Demonstrate Widespread Copy Number Alterations Also Found in Human ALL

Mouse Lymphoblastic Leukemias Induced by Aberrant Prdm14 Expression Demonstrate Widespread Copy Number Alterations Also Found in Human ALL

Aberrant expression and activation of oncogenes in somatic cells has been associated with cancer initiation. Required for reacquisition of pluripotency in the developing germ cell, PRDM14 initiates lymphoblastic leukemia when misexpressed in murine bone marrow. Activation of pluripotency in somatic...

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Bibliographic Details
Main Authors: Stephen J. Simko, Horatiu Voicu, Brandi L. Carofino, Monica J. Justice
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:Cancers
Subjects:
PRDM14
lymphoblastic leukemia
pluripotency
CGH
leukemia
DNA damage
DNA repair
CDKN2A
TBX2
Online Access:http://www.mdpi.com/2072-6694/4/4/1050

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