Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen

Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen

58-year-old man presented with headache, nausea, vomiting, and gait disturbance. Brain MRI showed meningeal enhancement and herniation. Serum Cryptococcus antigen was positive but spinal fluid antigen and cultures were negative. A cerebellar biopsy revealed nonencapsulated Cryptococcus. He completed...

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Main Authors: Rocio C. Garcia-Santibanez, Veenu Gill, Stanley Yancovitz, DeWitt Pyburn
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Case Reports in Infectious Diseases
Online Access:http://dx.doi.org/10.1155/2015/857539
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spelling doaj-15de29577eeb4574880aee8cd65c01452020-11-25T01:08:13ZengHindawi LimitedCase Reports in Infectious Diseases2090-66252090-66332015-01-01201510.1155/2015/857539857539Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus AntigenRocio C. Garcia-Santibanez0Veenu Gill1Stanley Yancovitz2DeWitt Pyburn3Department of Neurology, Mount Sinai Beth Israel, New York, NY 10003, USADepartment of Infectious Diseases, Mount Sinai Beth Israel, New York, NY 10003, USADepartment of Infectious Diseases, Mount Sinai Beth Israel, New York, NY 10003, USADepartment of Neurology, Mount Sinai Beth Israel, New York, NY 10003, USA58-year-old man presented with headache, nausea, vomiting, and gait disturbance. Brain MRI showed meningeal enhancement and herniation. Serum Cryptococcus antigen was positive but spinal fluid antigen and cultures were negative. A cerebellar biopsy revealed nonencapsulated Cryptococcus. He completed antifungal therapy. Serum Cryptococcus antigen titer decreased. He had a full neurological recovery.http://dx.doi.org/10.1155/2015/857539
collection DOAJ
language English
format Article
sources DOAJ
author Rocio C. Garcia-Santibanez
Veenu Gill
Stanley Yancovitz
DeWitt Pyburn
spellingShingle Rocio C. Garcia-Santibanez
Veenu Gill
Stanley Yancovitz
DeWitt Pyburn
Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen
Case Reports in Infectious Diseases
author_facet Rocio C. Garcia-Santibanez
Veenu Gill
Stanley Yancovitz
DeWitt Pyburn
author_sort Rocio C. Garcia-Santibanez
title Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen
title_short Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen
title_full Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen
title_fullStr Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen
title_full_unstemmed Neuroinvasive Cryptococcosis in an Immunocompetent Patient with a Negative Spinal Fluid Cryptococcus Antigen
title_sort neuroinvasive cryptococcosis in an immunocompetent patient with a negative spinal fluid cryptococcus antigen
publisher Hindawi Limited
series Case Reports in Infectious Diseases
issn 2090-6625
2090-6633
publishDate 2015-01-01
description 58-year-old man presented with headache, nausea, vomiting, and gait disturbance. Brain MRI showed meningeal enhancement and herniation. Serum Cryptococcus antigen was positive but spinal fluid antigen and cultures were negative. A cerebellar biopsy revealed nonencapsulated Cryptococcus. He completed antifungal therapy. Serum Cryptococcus antigen titer decreased. He had a full neurological recovery.
url http://dx.doi.org/10.1155/2015/857539
work_keys_str_mv AT rociocgarciasantibanez neuroinvasivecryptococcosisinanimmunocompetentpatientwithanegativespinalfluidcryptococcusantigen
AT veenugill neuroinvasivecryptococcosisinanimmunocompetentpatientwithanegativespinalfluidcryptococcusantigen
AT stanleyyancovitz neuroinvasivecryptococcosisinanimmunocompetentpatientwithanegativespinalfluidcryptococcusantigen
AT dewittpyburn neuroinvasivecryptococcosisinanimmunocompetentpatientwithanegativespinalfluidcryptococcusantigen
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