Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies

Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies

Taking advantage of the immune system to exert an antitumor effect is currently a novel approach in cancer therapy. Adoptive transfer of T cells engineered to express chimeric antigen receptors (CARs) targeting a desired antigen has shown extraordinary antitumor activity, especially in refractory an...

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Bibliographic Details
Main Authors: Jiali Cheng, Lei Zhao, Yuanyuan Zhang, Yun Qin, Yuqi Guan, Tong Zhang, Chaohong Liu, Jianfeng Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
CAR T-cell therapy
resistance mechanism
T-cell defect
tumor factor
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01237/full

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