Cancer Therapy Targeting the HER2-PI3K Pathway: Potential Impact on the Heart

The HER2-PI3K pathway is the one of the most mutated pathways in cancer. Several drugs targeting the major kinases of this pathway have been approved by the Food and Drug Administration and many are being tested in clinical trials for the treatment of various cancers. However, the HER2-PI3K pathway...

Full description

Bibliographic Details
Main Authors: Giannoula Lakka Klement, David eGoukassian, Lynn eHlatky, Joseph eCarrozza, James P. Morgan, Xinhua eYan
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00113/full