VHL inactivation without hypoxia is sufficient to achieve genome hypermethylation
Abstract VHL inactivation is a key oncogenic event for renal carcinomas. In normoxia, VHL suppresses HIF1a-mediated transcriptional response, which is characteristic to hypoxia. It has previously been shown that hypoxic conditions inhibit TET-dependent hydroxymethylation of cytosines and cause DNA h...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-28795-y |