MicroRNA-302a/d inhibits the self-renewal capability and cell cycle entry of liver cancer stem cells by targeting the E2F7/AKT axis

MicroRNA-302a/d inhibits the self-renewal capability and cell cycle entry of liver cancer stem cells by targeting the E2F7/AKT axis

Abstract Background There is increasing evidence that liver cancer stem cells (LCSCs) contribute to hepatocellular carcinoma (HCC) initiation and progression. MicroRNA (miRNA) plays a significant functional role by directly regulating respective targets in LCSCs-triggered HCC, however, little is kno...

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Bibliographic Details
Main Authors: Yu-Shui Ma, Zhong-Wei Lv, Fei Yu, Zheng-Yan Chang, Xian-Ling Cong, Xiao-Ming Zhong, Gai-Xia Lu, Jian Zhu, Da Fu
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HCC
LCSCs
miRNA-302a/d
E2F7
Prognosis
Online Access:http://link.springer.com/article/10.1186/s13046-018-0927-8

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