Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure

Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure

Peroxisome proliferator-activated receptor α (PPARα) is a key regulator to ameliorate liver injury in cases of acute liver failure (ALF). However, its regulatory mechanisms remain largely undetermined. Endoplasmic reticulum stress (ER stress) plays an important role in a number of liver diseases. Th...

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Bibliographic Details
Main Authors: Li Zhang, Feng Ren, Xiangying Zhang, Xinxin Wang, Hongbo Shi, Li Zhou, Sujun Zheng, Yu Chen, Dexi Chen, Liying Li, Caiyan Zhao, Zhongping Duan
Format: Article
Language:English
Published: The Company of Biologists 2016-07-01
Series:Disease Models & Mechanisms
Subjects:
Peroxisome proliferator-activated receptor α
Endoplasmic reticulum stress
Acute liver failure
Hepatotoxicity
Apoptosis
Online Access:http://dmm.biologists.org/content/9/7/799

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