Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition.

Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition.

mTOR is a central integrator of metabolic and immunological stimuli, dictating immune cell activation, proliferation and differentiation. In this study, we demonstrate that within a clonal population of activated T cells, there exist both mTORhi and mTORlo cells exhibiting highly divergent metabolic...

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Bibliographic Details
Main Authors: Kristen N Pollizzi, Adam T Waickman, Chirag H Patel, Im Hong Sun, Jonathan D Powell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4388710?pdf=render

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