Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers

Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers

<p>Abstract</p> <p>This is an in-depth review of the history of quinacrine as well as its pharmacokinetic properties and established record of safety as an FDA-approved drug. The potential uses of quinacrine as an anti-cancer agent are discussed with particular attention to its act...

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Bibliographic Details
Main Authors: Van Waes Carter, Ehsanian Reza, Feller Stephan M
Format: Article
Language:English
Published: BMC 2011-05-01
Series:Cell Communication and Signaling
Online Access:http://www.biosignaling.com/content/9/1/13
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spelling doaj-158873d0bd4c4131a276901ac7760feb2020-11-25T00:15:12ZengBMCCell Communication and Signaling1478-811X2011-05-01911310.1186/1478-811X-9-13Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancersVan Waes CarterEhsanian RezaFeller Stephan M<p>Abstract</p> <p>This is an in-depth review of the history of quinacrine as well as its pharmacokinetic properties and established record of safety as an FDA-approved drug. The potential uses of quinacrine as an anti-cancer agent are discussed with particular attention to its actions on nuclear proteins, the arachidonic acid pathway, and multi-drug resistance, as well as its actions on signaling proteins in the cytoplasm. In particular, quinacrine's role on the NF-κB, p53, and AKT pathways are summarized.</p> http://www.biosignaling.com/content/9/1/13
collection DOAJ
language English
format Article
sources DOAJ
author Van Waes Carter
Ehsanian Reza
Feller Stephan M
spellingShingle Van Waes Carter
Ehsanian Reza
Feller Stephan M
Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
Cell Communication and Signaling
author_facet Van Waes Carter
Ehsanian Reza
Feller Stephan M
author_sort Van Waes Carter
title Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
title_short Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
title_full Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
title_fullStr Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
title_full_unstemmed Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
title_sort beyond dna binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers
publisher BMC
series Cell Communication and Signaling
issn 1478-811X
publishDate 2011-05-01
description <p>Abstract</p> <p>This is an in-depth review of the history of quinacrine as well as its pharmacokinetic properties and established record of safety as an FDA-approved drug. The potential uses of quinacrine as an anti-cancer agent are discussed with particular attention to its actions on nuclear proteins, the arachidonic acid pathway, and multi-drug resistance, as well as its actions on signaling proteins in the cytoplasm. In particular, quinacrine's role on the NF-κB, p53, and AKT pathways are summarized.</p>
url http://www.biosignaling.com/content/9/1/13
work_keys_str_mv AT vanwaescarter beyonddnabindingareviewofthepotentialmechanismsmediatingquinacrinestherapeuticactivitiesinparasiticinfectionsinflammationandcancers
AT ehsanianreza beyonddnabindingareviewofthepotentialmechanismsmediatingquinacrinestherapeuticactivitiesinparasiticinfectionsinflammationandcancers
AT fellerstephanm beyonddnabindingareviewofthepotentialmechanismsmediatingquinacrinestherapeuticactivitiesinparasiticinfectionsinflammationandcancers
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