A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii

A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii

Modification of the outer membrane charge by a polymyxin B (PMB)-induced PmrAB two-component system appears to be a dominant phenomenon in PMB-resistant Acinetobacter baumannii. PMB-resistant variants and many clinical isolates also appeared to produce outer membrane vesicles (OMVs). Genomic, transc...

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Bibliographic Details
Main Authors: Jaeeun Park, Misung Kim, Bora Shin, Mingyeong Kang, Jihye Yang, Tae Kwon Lee, Woojun Park
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
acinetobacter baumannii
lps modifications
outer membrane vesicl
component regulatory systems
experimental evolution
polymyxin resistance
Online Access:https://elifesciences.org/articles/66988

Internet

https://elifesciences.org/articles/66988

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