Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones.

Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones.

TNFα-converting enzyme (TACE) is a membrane-bound proteolytic enzyme with essential roles in the functional regulation of TNFα and epidermal growth factor receptor (EGFR) ligands. Previous studies have demonstrated critical roles for TACE in vivo, including epidermal development, immune response, an...

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Bibliographic Details
Main Authors: Kenta Saito, Keisuke Horiuchi, Tokuhiro Kimura, Sakiko Mizuno, Masaki Yoda, Hideo Morioka, Haruhiko Akiyama, David Threadgill, Yasunori Okada, Yoshiaki Toyama, Kazuki Sato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3548805?pdf=render

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