PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol
Abstract Insights from inherited forms of parkinsonism suggest that insufficient mitophagy may be one etiology of the disease. PINK1/Parkin-dependent mitophagy, which helps maintain a healthy mitochondrial network, is initiated by activation of the PINK1 kinase specifically on damaged mitochondria....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-01-01
|
| Series: | BMC Biology |
| Online Access: | http://link.springer.com/article/10.1186/s12915-017-0470-7 |