Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway

Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway

Abstract Background Baicalin is a flavonoid compound that exerts specific pharmacological effect in attenuating the proliferation, migration, and apoptotic resistance of hypoxia-induced pulmonary artery smooth muscle cells (PASMCs). However, the underlying mechanism has not been fully elucidated yet...

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Bibliographic Details
Main Authors: Xiaoying Huang, Wei Mao, Ting Zhang, Meibin Wang, Xuetao Wang, Yaozhe Li, Lin Zhang, Dan Yao, Xueding Cai, Liangxing Wang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Hypoxia
PASMC
Proliferation
Migration
A2a receptor
SDF-1/CXCR4
Online Access:http://link.springer.com/article/10.1186/s12906-018-2364-9

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