Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives

Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives

A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives <strong>5a</strong>–<strong>g</strong> was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorid...

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Main Authors: Mine Yarim, Meric Koksal, Irem Durmaz, Rengul Atalay
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:International Journal of Molecular Sciences
Subjects:
1-(4-chlorobenzhydryl)piperazine derivatives
cell proliferation
benzoyl chlorides
cytotoxicity
cancer
Online Access:http://www.mdpi.com/1422-0067/13/7/8071
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spelling doaj-15532b28aad04842a2358c63b1d7fbab2020-11-24T20:43:31ZengMDPI AGInternational Journal of Molecular Sciences1422-00672012-06-011378071808510.3390/ijms13078071Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine DerivativesMine YarimMeric KoksalIrem DurmazRengul AtalayA series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives <strong>5a</strong>–<strong>g</strong> was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and <sup>1</sup>H nuclear magnetic resonance spectra. Cytotoxicity of the compounds was demonstrated on cancer cell lines from liver (HUH7, FOCUS, MAHLAVU, HEPG2, HEP3B), breast (MCF7, BT20, T47D, CAMA-1), colon (HCT-116), gastric (KATO-3) and endometrial (MFE-296) cancer cell lines. Time-dependent cytotoxicity analysis of compound <strong>5a</strong> indicated the long-term <em>in situ</em> stability of this compound. All compounds showed significant cell growth inhibitory activity on the selected cancer cell lines.http://www.mdpi.com/1422-0067/13/7/80711-(4-chlorobenzhydryl)piperazine derivativescell proliferationbenzoyl chloridescytotoxicitycancer
collection DOAJ
language English
format Article
sources DOAJ
author Mine Yarim
Meric Koksal
Irem Durmaz
Rengul Atalay
spellingShingle Mine Yarim
Meric Koksal
Irem Durmaz
Rengul Atalay
Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives
International Journal of Molecular Sciences
1-(4-chlorobenzhydryl)piperazine derivatives
cell proliferation
benzoyl chlorides
cytotoxicity
cancer
author_facet Mine Yarim
Meric Koksal
Irem Durmaz
Rengul Atalay
author_sort Mine Yarim
title Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives
title_short Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives
title_full Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives
title_fullStr Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives
title_full_unstemmed Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives
title_sort cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2012-06-01
description A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives <strong>5a</strong>–<strong>g</strong> was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and <sup>1</sup>H nuclear magnetic resonance spectra. Cytotoxicity of the compounds was demonstrated on cancer cell lines from liver (HUH7, FOCUS, MAHLAVU, HEPG2, HEP3B), breast (MCF7, BT20, T47D, CAMA-1), colon (HCT-116), gastric (KATO-3) and endometrial (MFE-296) cancer cell lines. Time-dependent cytotoxicity analysis of compound <strong>5a</strong> indicated the long-term <em>in situ</em> stability of this compound. All compounds showed significant cell growth inhibitory activity on the selected cancer cell lines.
topic 1-(4-chlorobenzhydryl)piperazine derivatives
cell proliferation
benzoyl chlorides
cytotoxicity
cancer
url http://www.mdpi.com/1422-0067/13/7/8071
work_keys_str_mv AT mineyarim cancercellcytotoxicitiesof14substitutedbenzoyl44chlorobenzhydrylpiperazinederivatives
AT merickoksal cancercellcytotoxicitiesof14substitutedbenzoyl44chlorobenzhydrylpiperazinederivatives
AT iremdurmaz cancercellcytotoxicitiesof14substitutedbenzoyl44chlorobenzhydrylpiperazinederivatives
AT rengulatalay cancercellcytotoxicitiesof14substitutedbenzoyl44chlorobenzhydrylpiperazinederivatives
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