Rodents Versus Pig Model for Assessing the Performance of Serotype Chimeric Ad5/3 Oncolytic Adenoviruses

Rodents Versus Pig Model for Assessing the Performance of Serotype Chimeric Ad5/3 Oncolytic Adenoviruses

Oncolytic adenoviruses (Ad) are promising tools for cancer therapeutics. Most Ad-based therapies utilize species C serotypes, with Adenovirus type 5 (Ad5) most commonly employed. Prior clinical trials demonstrated low efficiency of oncolytic Ad5 vectors, mainly due to the absence of Ad5 primary rece...

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Bibliographic Details
Main Authors: Lisa Koodie, Matthew G. Robertson, Malavika Chandrashekar, George Ruth, Michele Dunning, Richard W. Bianco, Julia Davydova
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cancers
Subjects:
oncolytic adenovirus
Ad5/3
Species B
serotype 3
animal model
preclinical model
replication
pig
porcine
syrian hamsters
Online Access:https://www.mdpi.com/2072-6694/11/2/198

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