Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse

Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse

Abstract During hearing in mammals, “sensorineural” inner hair cells convert sound wave-generated mechanical input into electrical activity, resulting in glutamate release onto type I spiral ganglion neurons (SGNs) at specialized synapses known as “ribbon synapses”. New findings published here in BM...

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Main Authors: Thomas M. Coate, Katherine Conant
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Biology
Online Access:http://link.springer.com/article/10.1186/s12915-018-0575-7
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spelling doaj-15408ccd460c42219dca52e1dfd7ddac2020-11-25T02:14:07ZengBMCBMC Biology1741-70072018-09-011611310.1186/s12915-018-0575-7Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapseThomas M. Coate0Katherine Conant1Department of Biology, Georgetown UniversityDepartment of Neuroscience, Georgetown University Medical CenterAbstract During hearing in mammals, “sensorineural” inner hair cells convert sound wave-generated mechanical input into electrical activity, resulting in glutamate release onto type I spiral ganglion neurons (SGNs) at specialized synapses known as “ribbon synapses”. New findings published here in BMC Biology by Sonntag and colleagues indicate a role for the proteoglycan Brevican in forming perineurounal net (PNN) baskets at these synapses and controlling the spatial distribution of presynaptic voltage-gated calcium channels that regulate glutamate release. These findings may provide insight into the mechanism by which individual ribbon synapses within a single hair cell can function in an independent manner to facilitate hearing within a broad dynamic range.http://link.springer.com/article/10.1186/s12915-018-0575-7
collection DOAJ
language English
format Article
sources DOAJ
author Thomas M. Coate
Katherine Conant
spellingShingle Thomas M. Coate
Katherine Conant
Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse
BMC Biology
author_facet Thomas M. Coate
Katherine Conant
author_sort Thomas M. Coate
title Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse
title_short Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse
title_full Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse
title_fullStr Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse
title_full_unstemmed Brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse
title_sort brevican “nets” voltage-gated calcium channels at the hair cell ribbon synapse
publisher BMC
series BMC Biology
issn 1741-7007
publishDate 2018-09-01
description Abstract During hearing in mammals, “sensorineural” inner hair cells convert sound wave-generated mechanical input into electrical activity, resulting in glutamate release onto type I spiral ganglion neurons (SGNs) at specialized synapses known as “ribbon synapses”. New findings published here in BMC Biology by Sonntag and colleagues indicate a role for the proteoglycan Brevican in forming perineurounal net (PNN) baskets at these synapses and controlling the spatial distribution of presynaptic voltage-gated calcium channels that regulate glutamate release. These findings may provide insight into the mechanism by which individual ribbon synapses within a single hair cell can function in an independent manner to facilitate hearing within a broad dynamic range.
url http://link.springer.com/article/10.1186/s12915-018-0575-7
work_keys_str_mv AT thomasmcoate brevicannetsvoltagegatedcalciumchannelsatthehaircellribbonsynapse
AT katherineconant brevicannetsvoltagegatedcalciumchannelsatthehaircellribbonsynapse
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