Assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial.

Assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial.

We consider a re-analysis of the wait-and-see (control) arm of a recent clinical trial on sciatica. While the original randomised trial was designed to evaluate the public policy effect of a conservative wait-and-see approach versus early surgery, we investigate the impact of surgery at the individu...

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Main Authors: Bart J A Mertens, Wilco C H Jacobs, Ronald Brand, Wilco C Peul
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4213022?pdf=render
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spelling doaj-1535b8553cf1406292af8e6ae0c897d92020-11-25T02:37:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e11132510.1371/journal.pone.0111325Assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial.Bart J A MertensWilco C H JacobsRonald BrandWilco C PeulWe consider a re-analysis of the wait-and-see (control) arm of a recent clinical trial on sciatica. While the original randomised trial was designed to evaluate the public policy effect of a conservative wait-and-see approach versus early surgery, we investigate the impact of surgery at the individual patient level in a re-analysis of the wait-and-see group data. Both marginal structural model re-weighted estimates as well as propensity score adjusted analyses are presented. Results indicate that patients with high propensity to receive surgery may have beneficial effects at 2 years from delayed disc surgery.http://europepmc.org/articles/PMC4213022?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Bart J A Mertens
Wilco C H Jacobs
Ronald Brand
Wilco C Peul
spellingShingle Bart J A Mertens
Wilco C H Jacobs
Ronald Brand
Wilco C Peul
Assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial.
PLoS ONE
author_facet Bart J A Mertens
Wilco C H Jacobs
Ronald Brand
Wilco C Peul
author_sort Bart J A Mertens
title Assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial.
title_short Assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial.
title_full Assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial.
title_fullStr Assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial.
title_full_unstemmed Assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial.
title_sort assessment of patient-specific surgery effect based on weighted estimation and propensity scoring in the re-analysis of the sciatica trial.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description We consider a re-analysis of the wait-and-see (control) arm of a recent clinical trial on sciatica. While the original randomised trial was designed to evaluate the public policy effect of a conservative wait-and-see approach versus early surgery, we investigate the impact of surgery at the individual patient level in a re-analysis of the wait-and-see group data. Both marginal structural model re-weighted estimates as well as propensity score adjusted analyses are presented. Results indicate that patients with high propensity to receive surgery may have beneficial effects at 2 years from delayed disc surgery.
url http://europepmc.org/articles/PMC4213022?pdf=render
work_keys_str_mv AT bartjamertens assessmentofpatientspecificsurgeryeffectbasedonweightedestimationandpropensityscoringinthereanalysisofthesciaticatrial
AT wilcochjacobs assessmentofpatientspecificsurgeryeffectbasedonweightedestimationandpropensityscoringinthereanalysisofthesciaticatrial
AT ronaldbrand assessmentofpatientspecificsurgeryeffectbasedonweightedestimationandpropensityscoringinthereanalysisofthesciaticatrial
AT wilcocpeul assessmentofpatientspecificsurgeryeffectbasedonweightedestimationandpropensityscoringinthereanalysisofthesciaticatrial
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