Design, efficient synthesis and molecular docking of some novel thiazolyl-pyrazole derivatives as anticancer agents

Design, efficient synthesis and molecular docking of some novel thiazolyl-pyrazole derivatives as anticancer agents

Abstract Pyrazoles, thiazoles and fused thiazoles have been reported to possess many biological activities. 3-Methyl-5-oxo-4-(2-arylhydrazono)-4,5-dihydro-1H-pyrazole-1-carbothioamides 3a,b (obtained from the reaction of ethyl 3-oxo-2-(2-arylhydrazono)butanoates 1a,b with thiosemicarbazide) could be...

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Bibliographic Details
Main Authors: Abdelwahed R. Sayed, Sobhi M. Gomha, Fathy M. Abdelrazek, Mohamed S. Farghaly, Shaimaa A. Hassan, Peter Metz
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Chemistry
Subjects:
Coupling reaction
Cyclocondensation
Hydrazonoyl halides
Pyrazolones
Anticancer activity
Molecular docking
Online Access:http://link.springer.com/article/10.1186/s13065-019-0632-5

Internet

http://link.springer.com/article/10.1186/s13065-019-0632-5

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