Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis.

Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis.

Hepatocellular carcinoma (HCC) is an aggressive tumor, with a high mortality rate due to late symptom presentation and frequent tumor recurrences and metastasis. It is also a rapidly growing tumor supported by different metabolic mechanisms; nevertheless, the biological and molecular mechanisms invo...

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Main Authors: Carmen Chak-Lui Wong, Sandy Leung-Kuen Au, Aki Pui-Wah Tse, Iris Ming-Jing Xu, Robin Kit-Ho Lai, David Kung-Chun Chiu, Larry Lai Wei, Dorothy Ngo-Yin Fan, Felice Ho-Ching Tsang, Regina Cheuk-Lam Lo, Chun-Ming Wong, Irene Oi-Lin Ng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4277479?pdf=render

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http://europepmc.org/articles/PMC4277479?pdf=render

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