Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice
Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid. The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-in...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/105120 |
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doaj-152fe2acb5bb4014a7b084a3a51436fb2020-11-24T20:44:47ZengHindawi LimitedMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/105120105120Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in MiceEdlene Lima Ribeiro0Karla Patricia de Souza Barbosa1Ingrid Tavares Fragoso2Mariana Aragão Matos Donato3Fabiana Oliveira dos Santos Gomes4Bruna Santos da Silva5Amanda Karolina Soares e Silva6Sura Wanessa Santos Rocha7Valdemiro Amaro da Silva Junior8Christina Alves Peixoto9Pós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, BrazilPós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, BrazilPós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, BrazilPós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, BrazilPós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, BrazilPós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, BrazilPós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, BrazilPós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartamento de Morfologia e Fisiologia Animal da Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, 52171-900 Recife, PE, BrazilLaboratório de Ultraestrutura, Instituto Aggeu Magalhães, FIOCRUZ, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-420 Recife, PE, BrazilDiethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid. The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-induced pleurisy). The injection of carrageenan into the pleural cavity induced the accumulation of fluid containing a large number of polymorphonuclear cells (PMNs) as well as infiltration of PMNs in lung tissues and increased production of nitrite and tumor necrosis factor-α and increased expression of interleukin-1β, cyclooxygenase (COX-2), and inducible nitric oxide synthase. Carrageenan also induced the expression of nuclear factor-κB. The oral administration of DEC (50 mg/Kg) three days prior to the carrageenan challenge led to a significant reduction in all inflammation markers. The present findings demonstrate that DEC is a potential drug for the treatment of acute lung inflammation.http://dx.doi.org/10.1155/2014/105120 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Edlene Lima Ribeiro Karla Patricia de Souza Barbosa Ingrid Tavares Fragoso Mariana Aragão Matos Donato Fabiana Oliveira dos Santos Gomes Bruna Santos da Silva Amanda Karolina Soares e Silva Sura Wanessa Santos Rocha Valdemiro Amaro da Silva Junior Christina Alves Peixoto |
| spellingShingle |
Edlene Lima Ribeiro Karla Patricia de Souza Barbosa Ingrid Tavares Fragoso Mariana Aragão Matos Donato Fabiana Oliveira dos Santos Gomes Bruna Santos da Silva Amanda Karolina Soares e Silva Sura Wanessa Santos Rocha Valdemiro Amaro da Silva Junior Christina Alves Peixoto Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice Mediators of Inflammation |
| author_facet |
Edlene Lima Ribeiro Karla Patricia de Souza Barbosa Ingrid Tavares Fragoso Mariana Aragão Matos Donato Fabiana Oliveira dos Santos Gomes Bruna Santos da Silva Amanda Karolina Soares e Silva Sura Wanessa Santos Rocha Valdemiro Amaro da Silva Junior Christina Alves Peixoto |
| author_sort |
Edlene Lima Ribeiro |
| title |
Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice |
| title_short |
Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice |
| title_full |
Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice |
| title_fullStr |
Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice |
| title_full_unstemmed |
Diethylcarbamazine Attenuates the Development of Carrageenan-Induced Lung Injury in Mice |
| title_sort |
diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice |
| publisher |
Hindawi Limited |
| series |
Mediators of Inflammation |
| issn |
0962-9351 1466-1861 |
| publishDate |
2014-01-01 |
| description |
Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid. The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-induced pleurisy). The injection of carrageenan into the pleural cavity induced the accumulation of fluid containing a large number of polymorphonuclear cells (PMNs) as well as infiltration of PMNs in lung tissues and increased production of nitrite and tumor necrosis factor-α and increased expression of interleukin-1β, cyclooxygenase (COX-2), and inducible nitric oxide synthase. Carrageenan also induced the expression of nuclear factor-κB. The oral administration of DEC (50 mg/Kg) three days prior to the carrageenan challenge led to a significant reduction in all inflammation markers. The present findings demonstrate that DEC is a potential drug for the treatment of acute lung inflammation. |
| url |
http://dx.doi.org/10.1155/2014/105120 |
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