Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites.

Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites.

Immunization with irradiated sporozoites is currently the most effective vaccination strategy against liver stages of malaria parasites, yet the mechanisms underpinning the success of this approach are unknown. Here we show that the complete development of protective CD8+ T cell responses requires p...

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Bibliographic Details
Main Authors: Ian A Cockburn, Yun-Chi Chen, Michael G Overstreet, Jason R Lees, Nico van Rooijen, Donna L Farber, Fidel Zavala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20463809/?tool=EBI

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