Characterization of ACE Inhibitors and AT<sub>1</sub>R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model

Characterization of ACE Inhibitors and AT<sub>1</sub>R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model

Blood-pressure-lowering drugs are proposed to foster SARS-CoV-2 infection by pharmacological upregulation of angiotensin-converting enzyme 2 (ACE2), the binding partner of the virus spike (S) protein, located on the surface of the host cells. Conversely, it is postulated that angiotensin–renin syste...

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Bibliographic Details
Main Authors: Philipp Reus, Ann-Kathrin Schneider, Thomas Ulshöfer, Marina Henke, Denisa Bojkova, Jindrich Cinatl, Sandra Ciesek, Gerd Geisslinger, Volker Laux, Mira Grättinger, Philip Gribbon, Susanne Schiffmann
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Life
Subjects:
ACE inhibitor
AT1 receptor antagonist
SARS-CoV-2
cell barrier integrity
Online Access:https://www.mdpi.com/2075-1729/11/8/810

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