2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication

The persistence of the AIDS epidemic, and the life-long treatment required, indicate the constant need of novel HIV-1 inhibitors. In this scenario the HIV-1 Reverse Transcriptase (RT)-associated ribonuclease H (RNase H) function is a promising drug target. Here we report a series of compounds, devel...

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Bibliographic Details
Main Authors: Angela Corona, Valentina Onnis, Claudia Del Vecchio, Francesca Esposito, Yung-Chi Cheng, Enzo Tramontano
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/25/6/1338