Nafld and cardiovascular risks: clinic, diagnostic, features of therapy
The relationship between non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD) is considered. The main mechanisms for increasing the cardiovascular risks induced by NAFLD are insulin resistance, oxidative stress, endothelial dysfunction and inflammation. Dyslipidemia, arterial...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2019-08-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/3138 |
| Summary: | The relationship between non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD) is considered. The main mechanisms for increasing the cardiovascular risks induced by NAFLD are insulin resistance, oxidative stress, endothelial dysfunction and inflammation. Dyslipidemia, arterial hypertension, type 2 diabetes mellitus, often present in patients with NAFLD, also contribute to an increase in cardiovascular risks. It is shown that with the progression of NAFLD, the risk of developing CVDs increases. Mortality of patients with NAFLD is mainly due to the development of CVD complications. Thus, NAFLD should be considered as an independent risk factor for CVD.Treatment of NAFLD includes lifestyle modification (diet therapy, physical activity), as well as the use of drugs from different groups: omega-3 polyunsaturated fatty acids, statins, S-adenosylmethionine, essential phospholipids, ursodeoxycholic acid, metadoxine, glycyrrhizic acid, vitamin E, herbal drugs. In particular, the use of phospholipides, which has a high safety profile and is well tolerated when used, including with a combination of NAFLD and CVD, is justified. |
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| ISSN: | 2079-701X 2658-5790 |