Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

Altered Insulin Signaling in Alzheimer’s Disease Brain – Special Emphasis on PI3K-Akt Pathway

Alzheimer’s disease (AD) and type 2 diabetes (T2D) are both diseases with increasing prevalence in aging populations. T2D, characterized by insulin resistance and defective insulin signaling, is a common co-morbidity and a risk factor for AD, increasing the risk approximately two to fourfold. Insuli...

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Bibliographic Details
Main Authors: Sami Gabbouj, Simo Ryhänen, Mikael Marttinen, Rebekka Wittrahm, Mari Takalo, Susanna Kemppainen, Henna Martiskainen, Heikki Tanila, Annakaisa Haapasalo, Mikko Hiltunen, Teemu Natunen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
type 2 diabetes
insulin
phosphatidylinositol-4
5-bisphosphate 3-kinase (PI3K)
Akt (Protein kinase B
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00629/full

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