Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M

Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M

Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs capable of rapidly producing copious amounts of type I IFN (IFN-I) in response to viral infections. The mechanism regulating rapid production of IFN-I after pDCs are exposed to viral nucleic acids remains elusive. Here, we show that...

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Bibliographic Details
Main Authors: Yi-An Ko, Yueh-Hsuan Chan, Chin-Hsiu Liu, Jian-Jong Liang, Tsung-Hsien Chuang, Yi-Ping Hsueh, Yi-Ling Lin, Kuo-I Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
plasmacytoid dendritic cell
type I interferon
Blimp-1
interleukin-1 receptor-associated kinase M
antiviral response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01828/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01828/full

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