Generation of Hutat2:Fc Knockin Primary Human Monocytes Using CRISPR/Cas9

Generation of Hutat2:Fc Knockin Primary Human Monocytes Using CRISPR/Cas9

The ability of monocytes to travel through the bloodstream, traverse tissue barriers, and aggregate at disease sites endows these cells with the attractive potential to carry therapeutic genes into the nervous system. However, gene editing in primary human monocytes has long been a challenge. Here,...

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Bibliographic Details
Main Authors: Bowen Wang, Jiahui Zuo, Wenzhen Kang, Qianqi Wei, Jianhui Li, Chunfu Wang, Zhihui Liu, Yuanan Lu, Yan Zhuang, Bianli Dang, Qing Liu, Wen Kang, Yongtao Sun
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
anti-Tat antibody
CRISPR/Cas9
knockin
primary monocytes
HIV-1
HIV-associated neurocognitive disorder
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253118300131

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http://www.sciencedirect.com/science/article/pii/S2162253118300131

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