Carnosine Prevents Type 2 Diabetes-Induced Osteoarthritis Through the ROS/NF-κB Pathway

Carnosine Prevents Type 2 Diabetes-Induced Osteoarthritis Through the ROS/NF-κB Pathway

Background: The anti-inflammatory and antioxidant capacity of carnosine (CAR) has been investigated in autoimmune diseases. The aim of this study was to evaluate the potential protective effects of oral CAR supplements to ameliorate type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats...

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Bibliographic Details
Main Authors: Yue Yang, Yang Wang, Yawei Kong, Xiaoning Zhang, He Zhang, Yi Gang, Lunhao Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
carnosine
osteoarthritis
type 2 diabetes mellitus
fibroblast-like synoviocyte
reactive oxygen species
NF-kappaB
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00598/full

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