PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord

PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord

Abstract Background Pyruvate kinase isozymes M2 (PKM2), as a member of pyruvate kinase family, plays a role of glycolytic enzyme in glucose metabolism. It also functions as protein kinase in cell proliferation, signaling, immunity, and gene transcription. In this study, the role of PKM2 in neuropath...

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Bibliographic Details
Main Authors: Binbin Wang, Siyuan Liu, Bingbing Fan, Xingguo Xu, Yonglin Chen, Rongxiang Lu, Zhongling Xu, Xiaojuan Liu
Format: Article
Language:English
Published: BMC 2018-01-01
Series:The Journal of Headache and Pain
Subjects:
PKM2
Neuropathic pain
Chronic constriction injury
Lactate
p-ERK
p-STAT
Online Access:http://link.springer.com/article/10.1186/s10194-018-0836-4

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