Synthesis, antiglycation and antioxidant potentials of benzimidazole derivatives

Synthesis, antiglycation and antioxidant potentials of benzimidazole derivatives

Benzimidazole derivatives 1–20 were synthesized and evaluated for antiglycation and antioxidant potentials. Among the series some analogs showed antiglycating potential ranging in between 182.30 ± 1.20 and 473.51 ± 2.17 when compared with standard rutin (IC50 value 295.09 ± 1.04 µM) and for antioxid...

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Main Authors: Muhammad Taha, Ashik Mosaddik, Fazal Rahim, Sajjad Ali, Mohamed Ibrahim, Noor Barak Almandil
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of King Saud University: Science
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364718304737
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spelling doaj-14f92ce244624b5fa218e6660000c8e52020-11-25T02:39:35ZengElsevierJournal of King Saud University: Science1018-36472020-01-01321191194Synthesis, antiglycation and antioxidant potentials of benzimidazole derivativesMuhammad Taha0Ashik Mosaddik1Fazal Rahim2Sajjad Ali3Mohamed Ibrahim4Noor Barak Almandil5Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi Arabia; Corresponding author.Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Chemistry, Hazara University, Mansehra 21300, PakistanDepartment of Chemistry, Karakoram International University, Gilgit-Baltistan, Gilgit 15100, PakistanDepartment of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaDepartment of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 31441, Saudi ArabiaBenzimidazole derivatives 1–20 were synthesized and evaluated for antiglycation and antioxidant potentials. Among the series some analogs showed antiglycating potential ranging in between 182.30 ± 1.20 and 473.51 ± 2.17 when compared with standard rutin (IC50 value 295.09 ± 1.04 µM) and for antioxidant potential ranging between 22.42 ± 0.26 and 82.30 ± 1.33 when compare with standard Propyl gallate (IC50 value 29.20 ± 1.25). Compound 2, 6, 10 and 19 showed potent antioxidant and antiglycation inhibitory potentials. Compounds 7, 11, 13, 15 and 20 showed moderate antiglycating potential with IC50 values 473.51 ± 2.17, 325.20 ± 1.70, 440.0 ± 3.60, 370.60 ± 2.80 and 415.20 ± 3.20 μM, and these compounds also showed excellent antioxidant potential with IC50 values 73.51 ± 1.17, 45.63 ± 0.92, 82.30 ± 1.33, 75.41 ± 1.51, 40.60 ± 0.80 and 64.92 ± 1.41 μM respectively. The remaining compounds 1, 3, 4, 5, 8, 9, 12, 14, 16, 17and 18 were found inactive. Keywords: Synthesis, Benzimidazole, Antiglycating, Antioxidant, SARhttp://www.sciencedirect.com/science/article/pii/S1018364718304737
collection DOAJ
language English
format Article
sources DOAJ
author Muhammad Taha
Ashik Mosaddik
Fazal Rahim
Sajjad Ali
Mohamed Ibrahim
Noor Barak Almandil
spellingShingle Muhammad Taha
Ashik Mosaddik
Fazal Rahim
Sajjad Ali
Mohamed Ibrahim
Noor Barak Almandil
Synthesis, antiglycation and antioxidant potentials of benzimidazole derivatives
Journal of King Saud University: Science
author_facet Muhammad Taha
Ashik Mosaddik
Fazal Rahim
Sajjad Ali
Mohamed Ibrahim
Noor Barak Almandil
author_sort Muhammad Taha
title Synthesis, antiglycation and antioxidant potentials of benzimidazole derivatives
title_short Synthesis, antiglycation and antioxidant potentials of benzimidazole derivatives
title_full Synthesis, antiglycation and antioxidant potentials of benzimidazole derivatives
title_fullStr Synthesis, antiglycation and antioxidant potentials of benzimidazole derivatives
title_full_unstemmed Synthesis, antiglycation and antioxidant potentials of benzimidazole derivatives
title_sort synthesis, antiglycation and antioxidant potentials of benzimidazole derivatives
publisher Elsevier
series Journal of King Saud University: Science
issn 1018-3647
publishDate 2020-01-01
description Benzimidazole derivatives 1–20 were synthesized and evaluated for antiglycation and antioxidant potentials. Among the series some analogs showed antiglycating potential ranging in between 182.30 ± 1.20 and 473.51 ± 2.17 when compared with standard rutin (IC50 value 295.09 ± 1.04 µM) and for antioxidant potential ranging between 22.42 ± 0.26 and 82.30 ± 1.33 when compare with standard Propyl gallate (IC50 value 29.20 ± 1.25). Compound 2, 6, 10 and 19 showed potent antioxidant and antiglycation inhibitory potentials. Compounds 7, 11, 13, 15 and 20 showed moderate antiglycating potential with IC50 values 473.51 ± 2.17, 325.20 ± 1.70, 440.0 ± 3.60, 370.60 ± 2.80 and 415.20 ± 3.20 μM, and these compounds also showed excellent antioxidant potential with IC50 values 73.51 ± 1.17, 45.63 ± 0.92, 82.30 ± 1.33, 75.41 ± 1.51, 40.60 ± 0.80 and 64.92 ± 1.41 μM respectively. The remaining compounds 1, 3, 4, 5, 8, 9, 12, 14, 16, 17and 18 were found inactive. Keywords: Synthesis, Benzimidazole, Antiglycating, Antioxidant, SAR
url http://www.sciencedirect.com/science/article/pii/S1018364718304737
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AT fazalrahim synthesisantiglycationandantioxidantpotentialsofbenzimidazolederivatives
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