A multi-enzymatic cascade reaction for the stereoselective production of γ-oxyfunctionalyzed amino acids

A multi-enzymatic cascade reaction for the stereoselective production of γ-oxyfunctionalyzed amino acids

A stereoselective three-enzyme cascade for synthesis of diasteromerically pure γ-oxyfunctionalized α-amino acids was developed. By coupling a dynamic kinetic resolution using an N-acylamino acid racemase and an L-selective aminoacylase from Geobacillus thermoglucosidasius with a stereoselective isol...

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Bibliographic Details
Main Authors: Junichi eEnoki, Jaqueline eMeisborn, Ann-Christin eMüller, Robert eKourist
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Microbiology
Subjects:
Amino Acids
Dynamic kinetic resolution
Asymmetric oxidation
Enzyme reaction
Isoleucine dioxygenase
Multi-enzyme cascade reaction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00425/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00425/full

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