Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures
RAD51 and DMC1 recombinases catalyse high-fidelity and mismatch tolerant recombination, processes that are indispensable for the maintenance of genomic integrity. Here, the authors via cryo-EM, molecular dynamics simulation and functional analysis elucidate the structural difference between RAD51 an...
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Bibliographic Details
| Main Authors: |
Shih-Chi Luo,
Hsin-Yi Yeh,
Wei-Hsuan Lan,
Yi-Min Wu,
Cheng-Han Yang,
Hao-Yen Chang,
Guan-Chin Su,
Chia-Yi Lee,
Wen-Jin Wu,
Hung-Wen Li,
Meng-Chiao Ho,
Peter Chi,
Ming-Daw Tsai |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-20258-1
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