Simultaneous Quantitation of a Novel α1/β1-Blocker TJ0711 and Its Two Metabolites in Dog Plasma Using LC-MS/MS and Its Application to a Pharmacokinetic Study after Intravenous Infusion

Simultaneous Quantitation of a Novel α1/β1-Blocker TJ0711 and Its Two Metabolites in Dog Plasma Using LC-MS/MS and Its Application to a Pharmacokinetic Study after Intravenous Infusion

TJ0711∙HCl, which is a novel α1/β1 adrenoceptor blocking agent with a ratio of 1:1 for α1/β1, is designed to treat and prevent perioperative hypertension. M1 and M3 were identified as important metabolites in vitro for either antihypertension activity or the maj...

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Bibliographic Details
Main Authors: Wenwen Zhu, Wanyu Liu, Haojv Li, Guojia Xu, Qian Li, Jiangeng Huang, Gao Li, Luqin Si
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Pharmaceutics
Subjects:
TJ0711
LC-MS/MS
pharmacokinetics
metabolite
beagle dog
Online Access:http://www.mdpi.com/1999-4923/11/1/38

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