Dual R108K and G189D Mutations in the NS1 Protein of A/H1N1 Influenza Virus Counteract Host Innate Immune Responses

Dual R108K and G189D Mutations in the NS1 Protein of A/H1N1 Influenza Virus Counteract Host Innate Immune Responses

Influenza A viruses (IAV) modulate host antiviral responses to promote growth and pathogenicity. Here, we examined the multifunctional IAV nonstructural protein 1 (NS1) of influenza A virus to better understand factors that contribute to viral replication efficiency or pathogenicity. In 2009, a pand...

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Bibliographic Details
Main Authors: Meng-Ting Huang, Sen Zhang, Ya-Nan Wu, Wei Li, Yu-Chang Li, Chang-Shuai Zhou, Xiao-Ping Kang, Tao Jiang
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Viruses
Subjects:
influenza A virus
NS1 protein
mutation
immune escape
Online Access:https://www.mdpi.com/1999-4915/13/5/905

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