Reducing Bias of Allele Frequency Estimates by Modeling SNP Genotype Data with Informative Missingness

Reducing Bias of Allele Frequency Estimates by Modeling SNP Genotype Data with Informative Missingness

The presence of missing single-nucleotide polymorphism (SNP) genotypes is common in genetic data. For studies with low-density SNPs, the most commonly used approach to deal with genotype missingness is to simply remove the observations with missing genotypes from the analyses. This naïve me...

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Bibliographic Details
Main Authors: Wan-Yu eLin, Nianjun eLiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Genetics
Subjects:
Allele frequency
EM algorithm
Genotype
Informative missingness
Missing at random
Single-nucleotide polymorphism
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00107/full

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