Genotoxicity of plant extracts

• Main Authors: Vera M. F. Vargas, Régis R. Guidobono, João A. P. Henriques
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 1991-01-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: Ames test; flovonoids; tannins; plant extracts; Achyrocline satureoides; Luehea divaricata; Baccharis anomala
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600017

Aqueous extracts of seven species used in Brazilian popular medicine (Achyrocline satureoides, Iodina rhombifolia, Desmodium incanum, Baccharis anomala, Tibouchina asperior, Luehea divaricata, Maytenus ilicifolia) were screened to the presence of mutagenic activity in the Ames test (Salmonella/microsome). Positive results were obtained for A. satureoides, B anomala and L. divaricata with microsomal activation. As shown elsewhere (Vargas et al., 1990) the metabolites of A. satureoides extract also show the capacity to induce prophage and/or SOS response in microscreen phage induction assay and SOS spot chromotest.