The Role of Antibodies in the Pathogenesis of Multiple Sclerosis

The Role of Antibodies in the Pathogenesis of Multiple Sclerosis

The presence of persistent intrathecal oligoclonal immunoglobulin G (IgG) bands (OCBs) and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Despite extensive investigations, the role of antibodies, the products of mature CD19+ B cells, in disease development...

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Bibliographic Details
Main Authors: Xiaoli Yu, Michael Graner, Peter G. E. Kennedy, Yiting Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neurology
Subjects:
multiple sclerosis
antibody
oligoclonal bands
immunoglobulin G
cytotoxicity
cerebrospinal fluid
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.533388/full

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