Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo

Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo

Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption. Methods: The Biopharmaceutic Classification System (BCS) category was determined using equilibrium solubility,...

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Bibliographic Details
Main Authors: Yang Liu, Jing Sun, Linying Zhong, Yu Li, A Na Er, Tong Li, Le Yang, Ling Dong
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Journal of Traditional Chinese Medical Sciences
Subjects:
Biopharmaceutical classification system
Baicalein
Intrinsic dissolution rate
In situ intestinal perfusion
Physiologically based pharmacokinetics
Absorption properties
Online Access:http://www.sciencedirect.com/science/article/pii/S2095754821000491

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