The HIST1 Locus Escapes Reprogramming in Cloned Bovine Embryos

The HIST1 Locus Escapes Reprogramming in Cloned Bovine Embryos

Epigenetic reprogramming is necessary in somatic cell nuclear transfer (SCNT) embryos in order to erase the differentiation-associated epigenetic marks of donor cells. However, such epigenetic memories often persist throughout the course of clonal development, thus decreasing cloning efficiency. Her...

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Bibliographic Details
Main Authors: Byungkuk Min, Sunwha Cho, Jung Sun Park, Kyuheum Jeon, Yong-Kook Kang
Format: Article
Language:English
Published: Oxford University Press 2016-05-01
Series:G3: Genes, Genomes, Genetics
Subjects:
RNA-seq
SCNT
HIST1 cluster
reprogramming
epigenetics
HDAC inhibitor
DNA methylation
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.115.026666

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