Glycogen Synthase Kinase 3α Is the Main Isoform That Regulates the Transcription Factors Nuclear Factor-Kappa B and cAMP Response Element Binding in Bovine Endothelial Cells Infected with Staphylococcus aureus

Glycogen Synthase Kinase 3α Is the Main Isoform That Regulates the Transcription Factors Nuclear Factor-Kappa B and cAMP Response Element Binding in Bovine Endothelial Cells Infected with Staphylococcus aureus

Glycogen synthase kinase 3 (GSK3) is a constitutive enzyme implicated in the regulation of cytokine expression and the inflammatory response during bacterial infections. Mammals have two GSK3 isoforms named GSK3α and GSK3β that plays different but often overlapping functions. Although the role of GS...

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Bibliographic Details
Main Authors: Octavio Silva-García, Rosa Rico-Mata, María Cristina Maldonado-Pichardo, Alejandro Bravo-Patiño, Juan J. Valdez-Alarcón, Jorge Aguirre-González, Víctor M. Baizabal-Aguirre
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
inflammatory response
endothelial cells
Staphylococcus aureus
glycogen synthase kinase 3
nuclear factor-kappa B
cAMP response element binding
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00092/full

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