Astrocytic GABA Accumulation in Experimental Temporal Lobe Epilepsy

An imbalance of excitation and inhibition has been associated with the pathophysiology of epilepsy. Loss of GABAergic interneurons and/or synaptic inhibition has been shown in various epilepsy models and in human epilepsy. Despite this loss, several studies reported preserved or increased tonic GABA...

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Bibliographic Details
Main Authors: Julia Müller, Aline Timmermann, Lukas Henning, Hendrik Müller, Christian Steinhäuser, Peter Bedner
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neurology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2020.614923/full