The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism

The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism

RecQ helicases are important for maintaining genomic integrity. Here, the authors present functional data and the crystal structure of human RecQ4, which exerts a helicase mechanism that may be more closely related to bacterial RecQ helicases than to its human family members.

Bibliographic Details
Main Authors: Sebastian Kaiser, Florian Sauer, Caroline Kisker
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15907
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spelling doaj-147d31ce692b44a8aba126cc52fb6e052021-05-11T07:42:27ZengNature Publishing GroupNature Communications2041-17232017-06-018111210.1038/ncomms15907The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanismSebastian Kaiser0Florian Sauer1Caroline Kisker2Rudolf-Virchow-Center for Experimental Biomedicine, Institute of Structural BiologyRudolf-Virchow-Center for Experimental Biomedicine, Institute of Structural BiologyRudolf-Virchow-Center for Experimental Biomedicine, Institute of Structural BiologyRecQ helicases are important for maintaining genomic integrity. Here, the authors present functional data and the crystal structure of human RecQ4, which exerts a helicase mechanism that may be more closely related to bacterial RecQ helicases than to its human family members.https://doi.org/10.1038/ncomms15907
collection DOAJ
language English
format Article
sources DOAJ
author Sebastian Kaiser
Florian Sauer
Caroline Kisker
spellingShingle Sebastian Kaiser
Florian Sauer
Caroline Kisker
The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
Nature Communications
author_facet Sebastian Kaiser
Florian Sauer
Caroline Kisker
author_sort Sebastian Kaiser
title The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
title_short The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
title_full The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
title_fullStr The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
title_full_unstemmed The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
title_sort structural and functional characterization of human recq4 reveals insights into its helicase mechanism
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-06-01
description RecQ helicases are important for maintaining genomic integrity. Here, the authors present functional data and the crystal structure of human RecQ4, which exerts a helicase mechanism that may be more closely related to bacterial RecQ helicases than to its human family members.
url https://doi.org/10.1038/ncomms15907
work_keys_str_mv AT sebastiankaiser thestructuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism
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AT carolinekisker thestructuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism
AT sebastiankaiser structuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism
AT floriansauer structuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism
AT carolinekisker structuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism
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