Preclinical Testing of an Oncolytic Parvovirus: Standard Protoparvovirus H-1PV Efficiently Induces Osteosarcoma Cell Lysis In Vitro

Preclinical Testing of an Oncolytic Parvovirus: Standard Protoparvovirus H-1PV Efficiently Induces Osteosarcoma Cell Lysis In Vitro

Osteosarcoma is the most frequent malignant disease of the bone. On the basis of early clinical experience in the 1960s with H-1 protoparvovirus (H-1PV) in osteosarcoma patients, this effective oncolytic virus was selected for systematic preclinical testing on various osteosarcoma cell cultures. A p...

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Bibliographic Details
Main Authors: Carsten Geiss, Zoltán Kis, Barbara Leuchs, Monika Frank-Stöhr, Jörg R. Schlehofer, Jean Rommelaere, Christiane Dinsart, Jeannine Lacroix
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Viruses
Subjects:
osteosarcoma
protoparvovirus H-1 (H-1PV)
oncolytic virus
viral cytotoxicity
Online Access:https://www.mdpi.com/1999-4915/9/10/301

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