Carbohydrate-Based Adjuvants for Vaccine Production

• Main Authors: S. S. Kurashova, T. K. Dzagurova, A. A. Ishmukhametov, M. S. Egorova, M. V. Balovneva, S. E. Sotskova, E. A. Tkachenko
• Format: Article
• Language: Russian
• Published: Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» 2018-06-01
• Series: Биопрепараты: Профилактика, диагностика, лечение
• Subjects: adjuvant; humoral immunity; polysaccharides; immunogenicity; vaccine safety; live vector vaccines; immunity; immunological activity of polysaccharides
• Online Access: https://www.biopreparations.ru/jour/article/view/134

Addition of adjuvants is a generally recognized method of enhancing the immunogenicity of vaccines. There is a large variety of  adjuvants, therefore the choice of an adjuvant is based on the  comparison of adjuvants efficacy in animal models, as well as  assessment of their safety and tolerability. There are many different  groups of substances that may have adjuvant properties, but  relatively little attention is paid to carbohydrate-based adjuvants, despite the fact that they are compatible with live vector  vaccines, safe, well tolerated, and their production is not laborious.  Thanks to these advantages the use of these particular adjuvants in  combination with any type of vaccine, including vector vaccines and  DNA vaccines, may be most appropriate and promising. This review  examines various types of carbohydrate adjuvants and the  mechanisms that determine their efficacy.