A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus

A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus

<p>Abstract</p> <p>Background</p> <p>The major hurdle in the treatment of Human Immunodeficiency virus type 1 (HIV-1) includes the development of drug resistance-associated mutations in the target regions of the virus. Since reverse transcriptase (RT) is essential for H...

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Bibliographic Details
Main Authors: Crumpacker Clyde S, Nurpeisov Viktoria, Rimland David, Chunduri HimaBindu, Sharma Prem L
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Virology Journal
Online Access:http://www.virologyj.com/content/8/1/33

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