Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women

Aging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) par...

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Main Authors: Kishiko Ogawa, Kiyoshi Sanada, Shuichi Machida, Mitsuharu Okutsu, Katsuhiko Suzuki
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2010/171023
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spelling doaj-146e3fbb485d4baaa1cba2c588f4f34a2020-11-24T21:06:20ZengHindawi LimitedMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/171023171023Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly WomenKishiko Ogawa0Kiyoshi Sanada1Shuichi Machida2Mitsuharu Okutsu3Katsuhiko Suzuki4Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi, Tokyo 173-0015, JapanConsolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumakicho Shinjuku, Tokyo 162-0041, JapanConsolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumakicho Shinjuku, Tokyo 162-0041, JapanConsolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumakicho Shinjuku, Tokyo 162-0041, JapanConsolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumakicho Shinjuku, Tokyo 162-0041, JapanAging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) participated in 12 weeks of resistance exercise training. Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. Training reduced the circulating levels of CRP, SAA (P<.05), HSP70, IGF-I, and insulin (P<.01). The training-induced reductions in CRP and TNF-α were significantly (P<.01, P<.05) associated with increased muscle thickness (r=−0.61, r=−0.54), respectively. None of the results were significant after applying a Bonferroni correction. Resistance training may assist in maintaining or improving muscle volume and reducing low-grade inflammation.http://dx.doi.org/10.1155/2010/171023
collection DOAJ
language English
format Article
sources DOAJ
author Kishiko Ogawa
Kiyoshi Sanada
Shuichi Machida
Mitsuharu Okutsu
Katsuhiko Suzuki
spellingShingle Kishiko Ogawa
Kiyoshi Sanada
Shuichi Machida
Mitsuharu Okutsu
Katsuhiko Suzuki
Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women
Mediators of Inflammation
author_facet Kishiko Ogawa
Kiyoshi Sanada
Shuichi Machida
Mitsuharu Okutsu
Katsuhiko Suzuki
author_sort Kishiko Ogawa
title Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women
title_short Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women
title_full Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women
title_fullStr Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women
title_full_unstemmed Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women
title_sort resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 2010-01-01
description Aging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) participated in 12 weeks of resistance exercise training. Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. Training reduced the circulating levels of CRP, SAA (P<.05), HSP70, IGF-I, and insulin (P<.01). The training-induced reductions in CRP and TNF-α were significantly (P<.01, P<.05) associated with increased muscle thickness (r=−0.61, r=−0.54), respectively. None of the results were significant after applying a Bonferroni correction. Resistance training may assist in maintaining or improving muscle volume and reducing low-grade inflammation.
url http://dx.doi.org/10.1155/2010/171023
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