Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women
Aging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) par...
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Online Access: | http://dx.doi.org/10.1155/2010/171023 |
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doaj-146e3fbb485d4baaa1cba2c588f4f34a2020-11-24T21:06:20ZengHindawi LimitedMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/171023171023Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly WomenKishiko Ogawa0Kiyoshi Sanada1Shuichi Machida2Mitsuharu Okutsu3Katsuhiko Suzuki4Research Team for Social Participation and Health Promotion, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi, Tokyo 173-0015, JapanConsolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumakicho Shinjuku, Tokyo 162-0041, JapanConsolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumakicho Shinjuku, Tokyo 162-0041, JapanConsolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumakicho Shinjuku, Tokyo 162-0041, JapanConsolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumakicho Shinjuku, Tokyo 162-0041, JapanAging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) participated in 12 weeks of resistance exercise training. Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. Training reduced the circulating levels of CRP, SAA (P<.05), HSP70, IGF-I, and insulin (P<.01). The training-induced reductions in CRP and TNF-α were significantly (P<.01, P<.05) associated with increased muscle thickness (r=−0.61, r=−0.54), respectively. None of the results were significant after applying a Bonferroni correction. Resistance training may assist in maintaining or improving muscle volume and reducing low-grade inflammation.http://dx.doi.org/10.1155/2010/171023 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kishiko Ogawa Kiyoshi Sanada Shuichi Machida Mitsuharu Okutsu Katsuhiko Suzuki |
spellingShingle |
Kishiko Ogawa Kiyoshi Sanada Shuichi Machida Mitsuharu Okutsu Katsuhiko Suzuki Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women Mediators of Inflammation |
author_facet |
Kishiko Ogawa Kiyoshi Sanada Shuichi Machida Mitsuharu Okutsu Katsuhiko Suzuki |
author_sort |
Kishiko Ogawa |
title |
Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women |
title_short |
Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women |
title_full |
Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women |
title_fullStr |
Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women |
title_full_unstemmed |
Resistance Exercise Training-Induced Muscle Hypertrophy Was Associated with Reduction of Inflammatory Markers in Elderly Women |
title_sort |
resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2010-01-01 |
description |
Aging is associated with low-grade inflammation. The benefits of regular exercise for the elderly are well established, whereas less is known about the impact of low-intensity resistance exercise on low-grade inflammation in the elderly. Twenty-one elderly women (mean age ± SD, 85.0 ± 4.5 years) participated in 12 weeks of resistance exercise training. Muscle thickness and circulating levels of C-reactive protein (CRP), serum amyloid A (SAA), heat shock protein (HSP)70, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, monocyte chemotactic protein (MCP-1), insulin, insulin-like growth factor (IGF)-I, and vascular endothelial growth factor (VEGF) were measured before and after the exercise training. Training reduced the circulating levels of CRP, SAA (P<.05), HSP70, IGF-I, and insulin (P<.01). The training-induced reductions in CRP and TNF-α were significantly (P<.01, P<.05) associated with increased muscle thickness (r=−0.61, r=−0.54), respectively. None of the results were significant after applying a Bonferroni correction. Resistance training may assist in maintaining or improving muscle volume and reducing low-grade inflammation. |
url |
http://dx.doi.org/10.1155/2010/171023 |
work_keys_str_mv |
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1716765812520386560 |