The Neurobiology of Panic: A Chronic Stress Disorder

Panic disorder is an often chronic and impairing human anxiety syndrome, which frequently results in serious psychiatric and medical comorbidities. Although, to date, there have been many advances in the diagnosis and treatment of panic disorder, its pathophysiology still remains to be elucidated. I...

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Main Author: Andrew W. Goddard
Format: Article
Language:English
Published: SAGE Publishing 2017-11-01
Series:Chronic Stress
Online Access:https://doi.org/10.1177/2470547017736038
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spelling doaj-146d9d181cef4de59708cbc397022a972020-11-25T03:13:24ZengSAGE PublishingChronic Stress2470-54702017-11-01110.1177/2470547017736038The Neurobiology of Panic: A Chronic Stress DisorderAndrew W. GoddardPanic disorder is an often chronic and impairing human anxiety syndrome, which frequently results in serious psychiatric and medical comorbidities. Although, to date, there have been many advances in the diagnosis and treatment of panic disorder, its pathophysiology still remains to be elucidated. In this review, recent evidence for a neurobiological basis of panic disorder is reviewed with particular attention to risk factors such as genetic vulnerability, chronic stress, and temperament. In addition, neuroimaging data are reviewed which provides support for the concept of panic disorder as a fear network disorder. The potential impact of the National Institute of Mental Health Research Domain Criteria constructs of acute and chronic threats responses and their implications for the neurobiology of panic disorder are also discussed.https://doi.org/10.1177/2470547017736038
collection DOAJ
language English
format Article
sources DOAJ
author Andrew W. Goddard
spellingShingle Andrew W. Goddard
The Neurobiology of Panic: A Chronic Stress Disorder
Chronic Stress
author_facet Andrew W. Goddard
author_sort Andrew W. Goddard
title The Neurobiology of Panic: A Chronic Stress Disorder
title_short The Neurobiology of Panic: A Chronic Stress Disorder
title_full The Neurobiology of Panic: A Chronic Stress Disorder
title_fullStr The Neurobiology of Panic: A Chronic Stress Disorder
title_full_unstemmed The Neurobiology of Panic: A Chronic Stress Disorder
title_sort neurobiology of panic: a chronic stress disorder
publisher SAGE Publishing
series Chronic Stress
issn 2470-5470
publishDate 2017-11-01
description Panic disorder is an often chronic and impairing human anxiety syndrome, which frequently results in serious psychiatric and medical comorbidities. Although, to date, there have been many advances in the diagnosis and treatment of panic disorder, its pathophysiology still remains to be elucidated. In this review, recent evidence for a neurobiological basis of panic disorder is reviewed with particular attention to risk factors such as genetic vulnerability, chronic stress, and temperament. In addition, neuroimaging data are reviewed which provides support for the concept of panic disorder as a fear network disorder. The potential impact of the National Institute of Mental Health Research Domain Criteria constructs of acute and chronic threats responses and their implications for the neurobiology of panic disorder are also discussed.
url https://doi.org/10.1177/2470547017736038
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