The Neurobiology of Panic: A Chronic Stress Disorder
Panic disorder is an often chronic and impairing human anxiety syndrome, which frequently results in serious psychiatric and medical comorbidities. Although, to date, there have been many advances in the diagnosis and treatment of panic disorder, its pathophysiology still remains to be elucidated. I...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2017-11-01
|
Series: | Chronic Stress |
Online Access: | https://doi.org/10.1177/2470547017736038 |
id |
doaj-146d9d181cef4de59708cbc397022a97 |
---|---|
record_format |
Article |
spelling |
doaj-146d9d181cef4de59708cbc397022a972020-11-25T03:13:24ZengSAGE PublishingChronic Stress2470-54702017-11-01110.1177/2470547017736038The Neurobiology of Panic: A Chronic Stress DisorderAndrew W. GoddardPanic disorder is an often chronic and impairing human anxiety syndrome, which frequently results in serious psychiatric and medical comorbidities. Although, to date, there have been many advances in the diagnosis and treatment of panic disorder, its pathophysiology still remains to be elucidated. In this review, recent evidence for a neurobiological basis of panic disorder is reviewed with particular attention to risk factors such as genetic vulnerability, chronic stress, and temperament. In addition, neuroimaging data are reviewed which provides support for the concept of panic disorder as a fear network disorder. The potential impact of the National Institute of Mental Health Research Domain Criteria constructs of acute and chronic threats responses and their implications for the neurobiology of panic disorder are also discussed.https://doi.org/10.1177/2470547017736038 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andrew W. Goddard |
spellingShingle |
Andrew W. Goddard The Neurobiology of Panic: A Chronic Stress Disorder Chronic Stress |
author_facet |
Andrew W. Goddard |
author_sort |
Andrew W. Goddard |
title |
The Neurobiology of Panic: A Chronic Stress Disorder |
title_short |
The Neurobiology of Panic: A Chronic Stress Disorder |
title_full |
The Neurobiology of Panic: A Chronic Stress Disorder |
title_fullStr |
The Neurobiology of Panic: A Chronic Stress Disorder |
title_full_unstemmed |
The Neurobiology of Panic: A Chronic Stress Disorder |
title_sort |
neurobiology of panic: a chronic stress disorder |
publisher |
SAGE Publishing |
series |
Chronic Stress |
issn |
2470-5470 |
publishDate |
2017-11-01 |
description |
Panic disorder is an often chronic and impairing human anxiety syndrome, which frequently results in serious psychiatric and medical comorbidities. Although, to date, there have been many advances in the diagnosis and treatment of panic disorder, its pathophysiology still remains to be elucidated. In this review, recent evidence for a neurobiological basis of panic disorder is reviewed with particular attention to risk factors such as genetic vulnerability, chronic stress, and temperament. In addition, neuroimaging data are reviewed which provides support for the concept of panic disorder as a fear network disorder. The potential impact of the National Institute of Mental Health Research Domain Criteria constructs of acute and chronic threats responses and their implications for the neurobiology of panic disorder are also discussed. |
url |
https://doi.org/10.1177/2470547017736038 |
work_keys_str_mv |
AT andrewwgoddard theneurobiologyofpanicachronicstressdisorder AT andrewwgoddard neurobiologyofpanicachronicstressdisorder |
_version_ |
1724646980365320192 |