Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing. By forming high-affinity heterotriplex structures within the genome, PNAs have been used...

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Bibliographic Details
Main Authors: Nicholas G. Economos, Stanley Oyaghire, Elias Quijano, Adele S. Ricciardi, W. Mark Saltzman, Peter M. Glazer
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
peptide nucleic acids
pna
triplex
gene editing
structure
recombination
repair
nanoparticles
β-thalassemia
cystic fibrosis
Online Access:https://www.mdpi.com/1420-3049/25/3/735

Internet

https://www.mdpi.com/1420-3049/25/3/735

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