Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway

Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway

The current study aimed to encapsulate fluvastatin sodium (FVS), a member of the statins family possessing pleiotropic effects in rheumatoid arthritis (RA), into spanlastic nanovesicles (SNVs) for transdermal delivery. This novel delivery could surmount FVS associated oral encumbrances such as appar...

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Bibliographic Details
Main Authors: Shahira F. El Menshawe, Mohamed M. Nafady, Heba M. Aboud, Rasha M. Kharshoum, Asmaa Mohammed M. Hussein Elkelawy, Doaa S. Hamad
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
fluvastatin sodium
spanlastic nanovesicles
transdermal delivery
rheumatoid arthritis
p38 mapk
Online Access:http://dx.doi.org/10.1080/10717544.2019.1686087

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